immunophenotypic characterization of the leukemic b-cells from iranian patients with chronic lymphocytic leukemia: association between cd38 expression and disease progression

Authors

mohammad hojjat farasangi

department of immunology, school of public health, medical sciences /tehran university, tehran, iran mahmood jeddi-tehrani

immune and gene therapy lab, cancer center karolinska, karolinska hospital, stockholm, sweden seyed mohsen razavi

clinic of hematology and oncology, firozgar hospital, faculty of medicine, iran university of medical sciences ramazan ali sharifian

clinic of hematology and oncology, vali-asr hospital, faculty of medicine, medical sciences/ university of tehran ahmad shamsian khoramabadi

abstract

background: patients with b-cell chronic lymphocytic leukemia (b-cll) have hetero-geneous clinical courses, thus several biological parameters need to be added to the cur-rent clinical staging systems to predict disease outcome. recent immunophenotypic stud-ies performed mainly in western populations have demonstrated the prognostic value of cd38 and zap-70 expression in b-cll. objectives: to investigate the expression pat-tern of a variety of membrane antigens on leukemic cells from iranian patients with cll and to find out if there are any differences in the expression of these markers between in-dolent and progressive groups. methods: in the present study, peripheral blood samples from 87 iranian patients with b-cll were analysed by flow cytometry. results: in all cases, the neoplastic cells displayed b-cll phenotype (cd5+/cd19+/sig+). the vast ma-jority of the cases expressed cd23, but failed to stain for cd3 or cd14. the leukemic cells of most patients expressed cd27 (84/87, 95.4%) and cd45ro (74/87, 83.9%) molecules, suggesting a memory b-cell phenotype. comparison between the indolent (n=42) and progressive (n=37) patients revealed significantly higher frequency and inten-sity of cd38 expression in progressive group (40.5%) compared to indolent (11.9%) pa-tients (p

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Journal title:
iranian journal of immunology

جلد ۵، شماره ۱، صفحات ۲۵-۳۵

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